MentionFox lists 44 Biotech companies for 2025. Of them, 13 are Y Combinator companies (the newest batch here is Fall 2025, with 5); 2 filed a Form D notice with the SEC; 29 won an SBIR or STTR award. The median SBIR or STTR award in the table is $1.3M, across 29 awards.
Companies44
Y Combinator13
Form D filers2
SBIR/STTR winners29
Other years
All years (692) 2026 (467) 2024 (17) 2022 (28) 2021 (39) 2020 (25)
Biotech startups in 2025
| Company | What it does | Date | Amount | Round / stage | Record |
|---|---|---|---|---|---|
| Digital Biotechnologies, Inc. | Filed Dec 31, 2025 | $12.3M | SEC Form D | ||
| SLAM BioTherapeutics, Inc. | Filed Dec 29, 2025 | $1M | SEC Form D | ||
| Emergingdx Inc | Rapid, automated, multiplexed omics platform | Award starts Sep 26, 2025 | $1.3M | SBIR Phase II | Federal award record |
| Mapp Biopharmaceutical, Inc. | Development of highly potent human monoclonal for rsv immunoprophylaxis - project summary globally, respiratory syncytial virus (rsv)… | Award starts Sep 24, 2025 | $2M | SBIR Phase III | Federal award record |
| Microbiotix, Inc. | Novel benzyl-piperidine antifungal agents to treat intractable mucorales infections - title: novel benzyl-piperidine antifungal agents… | Award starts Sep 22, 2025 | $599,327 | STTR Phase I | Federal award record |
| Natsar Pharmaceuticals, Inc. | Drug development of rk-33 for breast cancer treatment - triple-negative breast cancers (tnbcs) are breast cancers that lack expression… | Award starts Sep 22, 2025 | $2.3M | SBIR Phase II | Federal award record |
| Mucommune LLC | In vivo engineering of multifaceted b7h3.car-t cells for cellular immunotherapy of pancreatic ductal adenocarcinoma - project summary… | Award starts Sep 16, 2025 | $2.3M | SBIR | Federal award record |
| Neurogt Inc | Trans-bbb aav9 gene therapy targeting cns neuropathy of mps i - project summary the goal of this phase ii sbir project is to further… | Award starts Sep 16, 2025 | $3M | SBIR Phase II | Federal award record |
| Allander Biotechnologies, Inc. | Human clinical trial of proprietary oral gel to treat radiation-induced oral mucositis in cancer patients - summary oral mucositis, a… | Award starts Sep 15, 2025 | $2.3M | SBIR Phase II | Federal award record |
| Biological Mimetics, Inc. | Biological mimetics, inc | Award starts Sep 15, 2025 | $1.5M | SBIR Phase II | Federal award record |
| Janusq LLC | In vivo efficacy and in vitro toxicity assessment of peptide-based therapy hv-3 for the treatment of huntington's disease - project… | Award starts Sep 15, 2025 | $698,011 | SBIR | Federal award record |
| L2 Diagnostics LLC | Pfag, a multivalent peptide vaccine against malaria - abstract pfag is our novel malaria vaccine, composed of short synthetic peptides… | Award starts Sep 15, 2025 | $599,954 | STTR Phase I | Federal award record |
| Vivid Bioinnovations, PBC | A novel cell sorting technology to enable investigation of rare cells in primary human tissues - abstract rare cells, such as pathogenic… | Award starts Sep 12, 2025 | $1.3M | SBIR | Federal award record |
| Fimbrion Therapeutics Inc | Pyridone compounds as novel antimycobacterial drugs for tuberculosis - project summary/abstract tuberculosis (tb), caused by infection… | Award starts Sep 9, 2025 | $600,000 | SBIR Phase II | Federal award record |
| Anto Biosciences | A Foundation Model for Microbial Communities. | Fall 2025 | Y Combinator batch | Y Combinator listing | |
| Exonic | Exonic is an AI-native cell and gene therapeutics company | Fall 2025 | Y Combinator batch | Y Combinator listing | |
| Nucleo | The first Agentic platform for Oncology | Fall 2025 | Y Combinator batch | Y Combinator listing | |
| Paceline Bio | Accelerating clinical ops for biotech & pharma | Fall 2025 | Y Combinator batch | Y Combinator listing | |
| Scoop | Automating regulatory submissions for life sciences | Fall 2025 | Y Combinator batch | Y Combinator listing | |
| Immport Therapeutics Inc | A sensitive and specific serology test for evaluating potency of whole cell pertussis vaccines - whooping cough (pertussis) is a highly… | Award starts Aug 25, 2025 | $592,254 | SBIR Phase II | Federal award record |
| Epoch Biotech, LLC | Preclinical efficacy of an apoe targeted antibody for alzheimer's disease - abstract we propose to challenge alzheimer’s disease (ad) by… | Award starts Aug 20, 2025 | $498,709 | STTR Phase I | Federal award record |
| Optimeos Life Sciences, Inc. | In vivo targeted delivery of nucleic acids to hematopoietic stem cells for treating primary immunodeficiencies - summary in this phase i… | Award starts Aug 19, 2025 | $600,000 | SBIR Phase I | Federal award record |
| Pumpkinseed Technologies Inc | High-throughput de-novo peptide sequencing with metasurface optics | Award starts Aug 1, 2025 | $1.2M | SBIR Phase II | Federal award record |
| Pearl Diagnostics, Inc. | A point of care urine test to aid diagnosis of aspergillosis - invasive aspergillosis (ia) was recently named by the who as an infection… | Award starts Jul 24, 2025 | $2M | STTR Phase I | Federal award record |
| Advanced Cooling Technologies Inc | Dha phase ii sbir psoralen-uv-a irradiation based high-throughput pathogen inactivation device | Award starts Jul 2, 2025 | $1.3M | SBIR Phase II | Federal award record |
| March Biosciences Inc | A phase 2 multi-center trial of cd5 car t-cell therapy in patients with t-cell lymphoma - abstract relapsed and refractory t-cell… | Award starts Jul 1, 2025 | $2.2M | SBIR Phase II | Federal award record |
| Sostos Inc. | An advanced web portal for artificial intelligence (AI)-based comprehensive discovery of repositioning drugs | Award starts Jul 1, 2025 | $1.2M | SBIR Phase II | Federal award record |
| Opto-atomics Corp | Proposal f2-17844 - nanoparticle on-demand loading system | Award starts Jun 25, 2025 | $1.7M | STTR Phase II | Federal award record |
| Astrocyte Pharmaceuticals Inc. | Preclinical efficacy and safety evaluation of oral ast-004 for moderate traumatic brain injury (tbi) - project summary traumatic brain… | Award starts Jun 12, 2025 | $3M | STTR Phase I | Federal award record |
| Cisterna Biologics, Inc. | Rapid and ultra-pure mrna production with next-generation RNA polymerases - project summary cisterna biologics is addressing critical… | Award starts Jun 5, 2025 | $350,000 | SBIR Phase I | Federal award record |
| b12 Labs | Making hard molecules for Pharma and Biotech | Summer 2025 | Y Combinator batch | Y Combinator listing | |
| Blank Bio | RNA intelligence for precision medicine | Summer 2025 | Y Combinator batch | Y Combinator listing | |
| Convexia | The world's first AI-maximalist pharma company | Summer 2025 | Y Combinator batch | Y Combinator listing | |
| Inaedis, Inc | Rapid dehydration and stabilization of biopharmaceutical formulations at room temperature | Award starts Jun 1, 2025 | $1.5M | SBIR Phase II | Federal award record |
| Verne Robotics | AI models that teach robots new skills in hours | Summer 2025 | Y Combinator batch | Y Combinator listing | |
| Jillion Therapeutics Inc. | Synergy between artificial intelligence and DNA-encoded library technologies to identify polypharmacological therapeutics for substance… | Award starts May 15, 2025 | $399,483 | SBIR Phase I | Federal award record |
| Stress Therapeutics, Inc. | Investigational new drug (ind)-enabling study for a new therapeutic for alcohol use disorder (aud) - summary | Award starts May 15, 2025 | $2M | SBIR Phase I | Federal award record |
| Bramante | Life sciences reagents and software | Spring 2025 | Y Combinator batch | Y Combinator listing | |
| Exoanalytic Solutions Inc | Small business innovative research (sbir) phase ii topic a244-064, exoanalytic solutions, inc. | Award starts Apr 1, 2025 | $2M | SBIR Phase II | Federal award record |
| Frekil | RWE Generation in minutes | Spring 2025 | Y Combinator batch | Y Combinator listing | |
| Myosin Therapeutics Inc | Phase 0/1b clinical trial of novel therapeutic agent mt-110 for the reduction of methamphetamine use - part 2 - project summary as of… | Award starts Apr 1, 2025 | $1.5M | SBIR Phase II | Federal award record |
| Mobile Health Interventions LLC | A comprehensive digital intervention to reduce heavy cannabis use - project abstract this sbir phase ii application, titled “a… | Award starts Feb 1, 2025 | $1.2M | SBIR Phase II | Federal award record |
| Exin Therapeutics | AI drug discovery platform for neurotherapeutics | Winter 2025 | Y Combinator batch | Y Combinator listing | |
| Uncommon Therapeutics | A Disease Focused Biotech, Building Multiple Billion Dollar Drugs | Winter 2025 | Y Combinator batch | Y Combinator listing |
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