Department of Health and Human Services, through National Institutes of Health, awarded Cisterna Biologics, Inc. of Oceanside, CA $350,000 under the SBIR program (Phase I), with work starting 2025-06-05 and running to 2027-05-31. It is one of 2 SBIR and STTR awards Cisterna Biologics, Inc. received in the last two years, $699,746 in all. Each figure links to the federal record.
The award
| Recipient | Cisterna Biologics, Inc. (Oceanside, CA) |
|---|---|
| Awarding agency | Department of Health and Human Services |
| Awarding office | National Institutes of Health |
| Phase | Phase I |
| Amount obligated | $350,000 |
| Period of performance starts | 2025-06-05 |
| Period of performance ends | 2027-05-31 |
| Award number | R41GM159477 (grant, CFDA 93.859) |
| Assistance listing | 93.859, Biomedical Research and Research Training |
| Signed | 2025-06-03 |
| Recipient registry id (UEI) | VGCCUDX8F5P5 |
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What it is for
Rapid and ultra-pure MRNA production with next-generation RNA polymerases - project summary cisterna biologics is addressing critical challenges in MRNA purification for therapeutic applications by developing a novel pro
Funding actions on this award
| Date | Action | Modification | Amount |
|---|---|---|---|
| 2026-03-06 | Revision | 000 | $0 |
| 2025-06-03 | New | 000 | $350,000 |
Rapid and ultra-pure MRNA production with next-generation RNA polymerases - project summary cisterna biologics is addressing critical challenges in MRNA purification for therapeutic applications by developing a novel production and purification process. This Phase I SBIR aims to generate ultra-pure MRNA, essential for high-dosage and frequent administration in treatments ranging from enzyme replacement to cancer immunotherapy. Traditional in vitro transcription (ivt) methods using T7 RNA polymerase produce significant byproducts that can trigger adverse immune responses. In collaboration with the university of texas-austin, cisterna's approach involves the development of cold-adapted (psychrophilic) RNA polymerases (rnaps), which maintain high activity at low temperatures and reduce byproduct formation. Additionally, cisterna's proprietary specific capture and cleavage (specc) purification technology intends to eliminate contaminants completely. The Phase I SBIR project will demonstrate the capability of this technology to synthesize contaminant-free MRNA, improving safety and efficacy for therapeutic use. Initial aims include optimizing psychrophilic rnaps and synthetic promoters to minimize contaminants significantly, with the ultimate goal of replacing current gold-standard purification methods. The successful completion of this phase will pave the way for Phase II, focusing ...
From the federal award record.
Other SBIR and STTR awards to Cisterna Biologics, Inc.
| Starts | Agency | Program | Amount | Project |
|---|---|---|---|---|
| 2025-08-01 | Department of Health and Human Services | SBIR Phase I | $349,746 | A novel approach to eliminate length impurities for high-quality MRNA production - project (record) |
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Get the free SnapshotWhere this comes from
The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs set aside part of federal research budgets for small companies. Agencies award them in phases: Phase I tests whether an idea is feasible, Phase II funds development, and Phase III is follow-on work paid for outside the set-aside. STTR awards also require a research institution as a partner.
Every figure on this page is taken from the award's own federal record, linked beside it, as it stood when the page was built: the recipient, its address, the awarding agency and office, the amount obligated so far, the dates and the description. Phase and program are shown as the award's own description states them. The amount can grow later if the agency adds funding to the same award.