We help oncologists and radiologists extract insights from CT scans to support tumor characterization and treatment. The hospitals we work with include Stanford Hospital, Cedars-Sinai, UCI Health, and Weill Cornell.
Nucleo is a Y Combinator company in the Fall 2025 batch. Its directory entry describes it as: The first Agentic platform for Oncology. The founders listed are Angelica Iacovelli (Founder/CEO), Luca Pegolotti (Founder/CTO) (Y Combinator directory entry, October 23, 2025).
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We help oncologists and radiologists extract insights from CT scans to support tumor characterization and treatment. The hospitals we work with include Stanford Hospital, Cedars-Sinai, UCI Health, and Weill Cornell.
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Advanced AI for oncological medical imaging. From scan to answer. In seconds, not hours.
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Angelica Iacovelli is the CEO and co-founder of Nucleo. Previously, she was a researcher at Stanford University, where she worked on cardiovascular modeling, simulating blood flow dynamics using GNNs, LSTMs, and Transformers. The models are now part of NVIDIA’s scientific libraries. She holds BS+MS in Mathematical Engineering from Politecnico di Milano and completed a research exchange at IIT Madras.
I am a researcher in Applied Mathematics and AI for healthcare by training. I hold degrees from Politecnico di Milano, Italy (BSc) and EPFL, Switzerland (MSc and PhD), and have conducted research at the Stanford School of Medicine during my PhD and as a Postdoc. Before founding Nucleo, I was part of Apple Health AI, where I worked on physics-informed machine learning. I've published papers on computational methods, cardiovascular system modeling, and AI for medical images and optical sensors.
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