Department of Health and Human Services, through National Institutes of Health, awarded Mucommune LLC of Durham, NC $2,292,701 under the SBIR program, with work starting 2025-09-16 and running to 2027-08-31. It is one of 3 SBIR and STTR awards Mucommune LLC received in the last two years, $5,356,553 in all. Each figure links to the federal record.
The award
| Recipient | Mucommune LLC (Durham, NC) |
|---|---|
| Awarding agency | Department of Health and Human Services |
| Awarding office | National Institutes of Health |
| Amount obligated | $2,292,701 |
| Period of performance starts | 2025-09-16 |
| Period of performance ends | 2027-08-31 |
| Award number | R44CA310402 (grant, CFDA 93.395) |
| Assistance listing | 93.395, Cancer Treatment Research |
| Place of performance | Morrisville, Wake County, NC |
| Signed | 2025-09-15 |
| Recipient registry id (UEI) | NWVPL2L4JMN8 |
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What it is for
In vivo engineering of multifaceted B7H3.car-t cells for cellular immunotherapy of pancreatic ductal adenocarcinoma - project summary t-cells modified with chimeric antigen receptor against unique cancer antigens i.e., c
Funding actions on this award
| Date | Action | Modification | Amount |
|---|---|---|---|
| 2026-08-13 | Continuation | 001 | $1,146,083 |
| 2026-01-09 | Revision | 000 | $0 |
| 2025-09-15 | New | 000 | $1,146,618 |
SBIR: In vivo engineering of multifaceted B7H3.car-t cells for cellular immunotherapy of pancreatic ductal adenocarcinoma - project summary t-cells modified with chimeric antigen receptor against unique cancer antigens i.e., car-t, represent a promising form of immunotherapy for cancer, but are currently limited by production time and costs to prepare the engineered t-cells ex vivo, as well as by modest efficacy against solid cancers due to poor tumor penetration. Rather than harvesting, activating, transducing, and expanding t-cells ex vivo, we believe direct engineering of car-t cells in vivo, by transducing circulating t-cells with high specificity, will reduce the time and cost of car-t therapy while also maximizing t-cell function by eliminating extended cultures in vitro. Mucommune has recently in-licensed a platform that enables exceptionally potent yet highly specific transduction of circulating t-cells, without first requiring t-cell activation, by combining both virological and chemical approaches. Specifically, IT utilizes a lv system incorporating the nipah virus fusion protein with its native tropism ablated and retargeted via ANTI-CD3 scfv, then formulates the resulting nipah lv (nlv) with a proprietary combo of transduction enhancers. To date, we have shown that this new system can specifically transduce non-activated t-cells among circulating pbmcs in vivo, gene ...
From the federal award record.
Other SBIR and STTR awards to Mucommune LLC
| Starts | Agency | Program | Amount | Project |
|---|---|---|---|---|
| 2026-09-11 | Department of Health and Human Services | SBIR | $1,006,467 | In vivo engineering of dual CD19/CD138 car-t cells for treatment of systemic lupus erythem (record) |
| 2025-09-11 | Department of Health and Human Services | SBIR | $2,057,385 | In vivo engineering of B7-H3.car-t cells for ovarian cancer therapy - project summary t-ce (record) |
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The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs set aside part of federal research budgets for small companies. Agencies award them in phases: Phase I tests whether an idea is feasible, Phase II funds development, and Phase III is follow-on work paid for outside the set-aside. STTR awards also require a research institution as a partner.
Every figure on this page is taken from the award's own federal record, linked beside it, as it stood when the page was built: the recipient, its address, the awarding agency and office, the amount obligated so far, the dates and the description. Phase and program are shown as the award's own description states them. The amount can grow later if the agency adds funding to the same award.