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Myosin Therapeutics Inc SBIR Phase II award

Award R44DA063266, starting 2025-04-01. Every figure below is from the federal award record.

Department of Health and Human Services, through National Institutes of Health, awarded Myosin Therapeutics Inc of Jupiter, FL $1,496,586 under the SBIR program (Phase II), with work starting 2025-04-01 and running to 2028-02-28. It is one of 2 SBIR and STTR awards Myosin Therapeutics Inc received in the last two years, $1,746,003 in all. Each figure links to the federal record.

The award

RecipientMyosin Therapeutics Inc (Jupiter, FL)
Awarding agencyDepartment of Health and Human Services
Awarding officeNational Institutes of Health
PhasePhase II
Amount obligated$1,496,586
Period of performance starts2025-04-01
Period of performance ends2028-02-28
Award numberR44DA063266 (grant, CFDA 93.279)
Assistance listing93.279, Drug Use and Addiction Research Programs
Place of performanceJupiter, Martin County, FL
Signed2025-03-18
Recipient registry id (UEI)MLH1HUK133H3

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What it is for

Phase 0/1B clinical trial of novel therapeutic agent MT-110 for the reduction of methamphetamine use - part 2 - project summary as of 2023, close to 2 million individuals in the united states are identified as having met

Funding actions on this award

DateActionModificationAmount
2026-04-03Revision000$0
2025-03-25Revision001$76,181
2025-03-18New000$1,420,405
Phase 0/1B clinical trial of novel therapeutic agent MT-110 for the reduction of methamphetamine use - part 2 - project summary as of 2023, close to 2 million individuals in the united states are identified as having methamphetamine use disorder (mud), with methamphetamine use rising significantly. Recent estimates suggest that this figure is underreported by about 225%, bringing the 2023 total closer to over 4 million people with mud, and likely even higher in 2024. Mud is a persistent condition for which there are no fda-approved medications at present. The current treatments available are behavioral modification therapies, which show limited success, as indicated by high relapse rates (60-90%). This underscores the need for an additional pharmacotherapy that targets relapse triggers to help maintain abstinence. Comprehensive prior studies by our group and others have shown that relapse induced by drug-use reminders (or “triggers”) exerts a strong motivational influence, posing a lifelong relapse risk regardless of the duration of abstinence. Myosin therapeutics is developing MT-110, a drug marked by the novel therapeutic target of the molecular motor nonmuscle myosin ii (nmii). Preclinical research has demonstrated that a single acute inhibition of nmii activity can produce a highly specific, long-lasting effect by restoring the brain’s structural plasticity to a pre-methamp ...

From the federal award record.

Other SBIR and STTR awards to Myosin Therapeutics Inc

StartsAgencyProgramAmountProject
2025-09-01Department of Health and Human ServicesSBIR$249,417Development of drug product to support a phase 0/1B dose escalation trial of MT-125 in rec (record)
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Where this comes from

The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs set aside part of federal research budgets for small companies. Agencies award them in phases: Phase I tests whether an idea is feasible, Phase II funds development, and Phase III is follow-on work paid for outside the set-aside. STTR awards also require a research institution as a partner.

Every figure on this page is taken from the award's own federal record, linked beside it, as it stood when the page was built: the recipient, its address, the awarding agency and office, the amount obligated so far, the dates and the description. Phase and program are shown as the award's own description states them. The amount can grow later if the agency adds funding to the same award.

Cite this page

Permanent URL: https://mentionfox.com/grants/myosin-therapeutics-r44da063266
Last updated 2026-09-30
Primary record: Federal award record
Myosin Therapeutics Inc: $1,496,586 SBIR Phase II award from HHS (2025). MentionFox, 2026-09-30. https://mentionfox.com/grants/myosin-therapeutics-r44da063266