Praxis Precision Medicines, Inc. has 25 Schedule 13D or 13G filings on record since 2025-07-22. 6 holders' latest filing reports 5% or more of common stock, par value $0.0001 per share. Each figure below is the holder's own, as filed, with the filing linked.
Holders
| Holder | Percent | Shares | Latest | Event date |
|---|---|---|---|---|
| Janus Henderson Group Plc | 12.3% | 2,763,859 | SCHEDULE 13G/A, 2025-11-14 | 2025-09-30 |
| Fmr LLC | 7.7% | 2,156,343 | SCHEDULE 13G/A, 2026-05-06 | 2026-03-31 |
| Perceptive Advisors LLC | 7.2% | 1,995,986 | SCHEDULE 13G/A, 2026-02-17 | 2025-12-31 |
| Baker Bros. Advisors LP | 6.3% | 1,753,198 | SCHEDULE 13G, 2026-05-15 | 2026-03-31 |
| Orbis Investment Management Ltd | 5.5% | 1,526,680 | SCHEDULE 13G/A, 2026-08-14 | 2026-06-30 |
| Vanguard Capital Management | 5.09% | 1,419,323 | SCHEDULE 13G, 2026-04-30 | 2026-03-31 |
| T. Rowe Price Associates, Inc. | 4.8% | 1,003,545 | SCHEDULE 13G/A, 2025-11-14 | 2025-09-30 |
| Soleus Capital Master Fund, L.P. | 4.6% | 966,740 | SCHEDULE 13G/A, 2025-08-05 | 2025-06-30 |
| Cormorant Asset Management, LP | 4% | 1,000,000 | SCHEDULE 13G/A, 2025-11-14 | 2025-09-30 |
| Adage Capital Management, L.P. | 3.83% | 965,313 | SCHEDULE 13G/A, 2026-02-12 | 2025-12-31 |
| Morgan Stanley | 2.9% | 617,980 | SCHEDULE 13G/A, 2025-11-07 | 2025-09-30 |
| Point72 Biotech Private Investments, LLC | 0.2% | 65,933 | SCHEDULE 13G/A, 2026-05-15 | 2026-03-31 |
| The Vanguard Group | 0% | 0 | SCHEDULE 13G/A, 2026-03-27 | 2026-03-13 |
Timeline
| Filed | Holder | Percent | Filing |
|---|---|---|---|
| 2025-07-22 | Perceptive Advisors LLC | 6.69% | SCHEDULE 13G |
| 2025-08-05 | Soleus Capital Master Fund, L.P. | 4.6% | SCHEDULE 13G/A |
| 2025-08-12 | Adage Capital Management, L.P. | 9.69% | SCHEDULE 13G/A |
| 2025-08-14 | Steven A. Cohen | 7.3% | SCHEDULE 13G/A |
| 2025-08-14 | Cormorant Asset Management, LP | 7.72% | SCHEDULE 13G/A |
| 2025-08-14 | Janus Henderson Group Plc | 12.4% | SCHEDULE 13G/A |
| 2025-09-02 | Adage Capital Management, L.P. | 11.28% | SCHEDULE 13G/A |
| 2025-11-03 | Adage Capital Management, L.P. | 5.29% | SCHEDULE 13G/A |
| 2025-11-07 | Morgan Stanley | 2.9% | SCHEDULE 13G/A |
| 2025-11-14 | T. Rowe Price Associates, Inc. | 4.8% | SCHEDULE 13G/A |
| 2025-11-14 | Steven A. Cohen | 9.6% | SCHEDULE 13G/A |
| 2025-11-14 | Cormorant Asset Management, LP | 4% | SCHEDULE 13G/A |
| 2025-11-14 | Janus Henderson Group Plc | 12.3% | SCHEDULE 13G/A |
| 2026-02-05 | Fmr LLC | 5.4% | SCHEDULE 13G |
| 2026-02-12 | Adage Capital Management, L.P. | 3.83% | SCHEDULE 13G/A |
| 2026-02-17 | Steven A. Cohen | 6.1% | SCHEDULE 13G/A |
| 2026-02-17 | Orbis Investment Management Ltd | 5% | SCHEDULE 13G |
| 2026-02-17 | Perceptive Advisors LLC | 7.2% | SCHEDULE 13G/A |
| 2026-03-27 | The Vanguard Group | 0% | SCHEDULE 13G/A |
| 2026-04-30 | Vanguard Capital Management | 5.09% | SCHEDULE 13G |
| 2026-05-06 | Fmr LLC | 7.7% | SCHEDULE 13G/A |
| 2026-05-15 | Point72 Biotech Private Investments, LLC | 0.2% | SCHEDULE 13G/A |
| 2026-05-15 | Orbis Investment Management Ltd | 8.9% | SCHEDULE 13G/A |
| 2026-05-15 | Baker Bros. Advisors LP | 6.3% | SCHEDULE 13G |
| 2026-08-14 | Orbis Investment Management Ltd | 5.5% | SCHEDULE 13G/A |
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Where this comes from
Anyone who comes to own more than 5% of a class of a listed company's voting shares has to tell the SEC. A holder who may seek to change or influence the company files Schedule 13D, and has to say in Item 4, "Purpose of Transaction", what it intends to do. A holder with no such intent, such as many index and passive funds, may file the shorter Schedule 13G. Both are amended when the stake changes, including when it falls below 5%.
Every row here is one of those filings, linked to the filing itself. Percentages and share counts are exactly as the holder filed them, for the holder the filing names; an amendment showing a lower figure is shown as filed. Item 4 text is quoted word for word. Where a 13D's Item 4 contains a sentence stating a definite intent to influence the company, that sentence is marked and quoted; the page does not describe the holder or its motives beyond the words it filed. Nothing here is investment advice.