As of November 6, 2026, 4 holders' latest Schedule 13D or 13G filings report owning 5% or more of Orchestra Biomed Holdings, Inc. The largest reported stake is RTW Investments, LP's, at 19.2%. 6 filings are on record since August 6, 2025 (Schedule 13D/A, April 29, 2026).
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Key facts
- · Reporting person: RTW Investments, LP · Sole voting: 0 · Shared voting: 11,942,394 · Sole dispositive: 0 · Shared dispositive: 11,942,394 · SCHEDULE 13D/A, 2026-04-29
- · Reporting person: Medtronic plc · Sole voting: 0 · Shared voting: 10,078,625 · Sole dispositive: 0 · Shared dispositive: 10,078,625 · SCHEDULE 13G/A, 2026-02-27
- · Holder: RTW Investments, LP · Percent: 19.7% · SCHEDULE 13D/A
- · Reporting person: Tasso Partners, LLC · Sole voting: 0 · Shared voting: 2,849,592 · Sole dispositive: 0 · Shared dispositive: 2,849,592 · SCHEDULE 13G, 2025-11-19
- · Holder: Perceptive Advisors LLC · Percent: 9.99% · SCHEDULE 13G/A
Orchestra Biomed Holdings, Inc. has 6 Schedule 13D or 13G filings on record since 2025-08-06. 4 holders' latest filing reports 5% or more of common stock, par value $0.0001 per share. Each figure below is the holder's own, as filed, with the filing linked.
Holders
| Holder | Percent | Shares | Latest | Event date |
|---|---|---|---|---|
| RTW Investments, LP | 19.2% | 11,942,394 | SCHEDULE 13D/A, 2026-04-29 | 2026-04-27 |
| Medtronic plc | 17.8% | 10,078,625 | SCHEDULE 13G/A, 2026-02-27 | 2025-12-31 |
| Perceptive Advisors LLC | 9.99% | 5,679,480 | SCHEDULE 13G/A, 2025-11-14 | 2025-09-30 |
| 5.5% | 3,098,592 | SCHEDULE 13G, 2025-11-19 | 2025-11-15 |
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More on Orchestra Biomed Holdings, Inc. and the records around it.
Orchestra Biomed Holdings, Inc. elsewhere on the record
Companies that share a holder
- Medtronic plc also filed stake reports on 2 other companies: Anteris Technologies Global Corp. (Jan 2026)
- Tasso Partners, LLC also filed stake reports on 2 other companies: PAVmed Inc. (Apr 2026), DarioHealth Corp. (Nov 2025)
- RTW Investments, LP also filed stake reports on 43 other companies: CG Oncology, Inc. (Aug 2026), iRhythm Holdings, Inc. (Aug 2026), Kailera Therapeutics, Inc. (Aug 2026)
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What the Full Report on Orchestra Biomed Holdings, Inc. covers
The Short Answer
Which Company This Is
What They Do, And How The Money Works
Who Runs It, And How To Reach Them
The Money: Funding, Valuation, Runway
Who Pays Them, And Who They Are Up Against
Warning Bells
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Voting and dispositive power, as filed
| Reporting person | Sole voting | Shared voting | Sole dispositive | Shared dispositive | Filing |
|---|---|---|---|---|---|
| RTW Investments, LP | 0 | 11,942,394 | 0 | 11,942,394 | SCHEDULE 13D/A, 2026-04-29 |
| RTW Master Fund, Ltd. | 0 | 5,820,915 | 0 | 5,820,915 | SCHEDULE 13D/A, 2026-04-29 |
| RTW Innovation Master Fund, Ltd. | 0 | 4,931,714 | 0 | 4,931,714 | SCHEDULE 13D/A, 2026-04-29 |
| Roderick Wong | 0 | 11,942,394 | 0 | 11,942,394 | SCHEDULE 13D/A, 2026-04-29 |
| Medtronic plc | 0 | 10,078,625 | 0 | 10,078,625 | SCHEDULE 13G/A, 2026-02-27 |
| Covidien Group S.a.r.l. | 0 | 10,078,625 | 0 | 10,078,625 | SCHEDULE 13G/A, 2026-02-27 |
| Tasso Partners, LLC | 0 | 2,849,592 | 0 | 2,849,592 | SCHEDULE 13G, 2025-11-19 |
| Dana Lorenzo | 249,000 | 2,849,592 | 249,000 | 2,849,592 | SCHEDULE 13G, 2025-11-19 |
The latest filing identifies Orchestra Biomed Holdings, Inc. by CUSIP 68572M106 and gives its principal executive office as 150 Union Square Drive, New Hope, PA 18938 (SCHEDULE 13D/A, 2026-04-29).
Source of funds (Item 3)
Item 3 of the Statement is hereby amended and supplemented as follows: On April 27, 2026, the RTW Funds exercised Pre-Funded Warrants to purchase an aggregate of 1,250,032 shares of the Issuer's common stock for $0.0001 a share. The RTW Funds exercised the Pre-Funded Warrants on a cashless basis, resulting in the Issuer's withholding 32 of such shares to satisfy the exercise price of the Pre-Funded Warrants, and the issuance to the RTW Funds of an aggregate of 1,250,000 shares.RTW Investments, LP, SCHEDULE 13D/A, 2026-04-29
Timeline
| Filed | Holder | Percent | Filing |
|---|---|---|---|
| 2025-08-06 | RTW Investments, LP | 15.4% | SCHEDULE 13D/A |
| 2025-11-14 | Perceptive Advisors LLC | 9.99% | SCHEDULE 13G/A |
| 2025-11-19 | Dana Lorenzo | 5.5% | SCHEDULE 13G |
| 2026-02-25 | RTW Investments, LP | 19.7% | SCHEDULE 13D/A |
| 2026-02-27 | Medtronic plc | 17.8% | SCHEDULE 13G/A |
| 2026-04-29 | RTW Investments, LP | 19.2% | SCHEDULE 13D/A |
Questions about who owns Orchestra Biomed Holdings, Inc.
Who owns Orchestra Biomed Holdings, Inc.?
On this page, 4 holders' latest ownership filings report 5% or more of Orchestra Biomed Holdings, Inc.: RTW Investments, LP (19.2%, Schedule 13D/A, filed 2026-04-29), Medtronic plc (17.8%, Schedule 13G/A, filed 2026-02-27), Perceptive Advisors LLC (9.99%, Schedule 13G/A, filed 2025-11-14) and Dana Lorenzo (5.5%, Schedule 13G, filed 2025-11-19).
Who are the largest shareholders of Orchestra Biomed Holdings, Inc.?
By the share each holder's latest filing reports, the largest holders of Orchestra Biomed Holdings, Inc. on this page are RTW Investments, LP (19.2%), Medtronic plc (17.8%) and Perceptive Advisors LLC (9.99%).
When did RTW Investments, LP buy into Orchestra Biomed Holdings, Inc.?
The filings give report dates, not purchase dates. The earliest filing from RTW Investments, LP on this page is the Schedule 13D/A, filed 2025-08-06, reporting 15.4%; its latest, Schedule 13D/A filed 2026-04-29, reports 19.2%. That earliest filing is itself an amendment, which updates an earlier report.
Is this an audit or a full list?
Neither. The ownership list on this page covers only Schedule 13D and 13G filings, which holders make once they own 5% or more of a class of shares (an amendment can report a stake that has since fallen below 5%); 6 such filings are shown here. It is not an audit and not a full cap table: holders who never reached 5% are not listed, and a stake can change after its latest filing.
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Where this comes from
Anyone who comes to own more than 5% of a class of a listed company's voting shares has to tell the SEC. A holder who may seek to change or influence the company files Schedule 13D, and has to say in Item 4, "Purpose of Transaction", what it intends to do. A holder with no such intent, such as many index and passive funds, may file the shorter Schedule 13G. Both are amended when the stake changes, including when it falls below 5%.
Every row here is one of those filings, linked to the filing itself. Percentages and share counts are exactly as the holder filed them, for the holder the filing names; an amendment showing a lower figure is shown as filed. Item 4 text is quoted word for word. Where a 13D's Item 4 contains a sentence stating a definite intent to influence the company, that sentence is marked and quoted; the page does not describe the holder or its motives beyond the words it filed. Nothing here is investment advice.