Amylyx Pharmaceuticals, Inc. has 16 Schedule 13D or 13G filings on record since 2025-07-17. 5 holders' latest filing reports 5% or more of common stock, $0.0001 par value per share. Each figure below is the holder's own, as filed, with the filing linked.
Holders
| Holder | Percent | Shares | Latest | Event date |
|---|---|---|---|---|
| Fmr LLC | 15% | 16,468,419 | SCHEDULE 13G/A, 2026-02-05 | 2025-12-31 |
| Perceptive Advisors LLC | 7.5% | 8,284,882 | SCHEDULE 13G/A, 2026-05-15 | 2026-03-31 |
| BlackRock, Inc. | 7.1% | 7,783,648 | SCHEDULE 13G/A, 2026-01-21 | 2025-12-31 |
| TCG Crossover GP II, LLC | 5.7% | 6,243,812 | SCHEDULE 13G/A, 2026-02-17 | 2025-12-31 |
| Commodore Capital LP | 5.1% | 5,650,000 | SCHEDULE 13G, 2025-11-17 | 2025-11-10 |
| Point72 Asset Management, L.P. | 2.6% | 2,801,636 | SCHEDULE 13G/A, 2025-11-14 | 2025-09-30 |
| Adage Capital Management, L.P. | 2.53% | 2,777,055 | SCHEDULE 13G/A, 2026-02-12 | 2025-12-31 |
| The Vanguard Group | 0% | 0 | SCHEDULE 13G/A, 2026-03-26 | 2026-03-13 |
Timeline
| Filed | Holder | Percent | Filing |
|---|---|---|---|
| 2025-07-17 | BlackRock, Inc. | 5.5% | SCHEDULE 13G |
| 2025-07-29 | The Vanguard Group | 5.04% | SCHEDULE 13G |
| 2025-08-12 | Adage Capital Management, L.P. | 9.87% | SCHEDULE 13G/A |
| 2025-10-07 | Fmr LLC | 10.7% | SCHEDULE 13G |
| 2025-10-30 | The Vanguard Group | 4.94% | SCHEDULE 13G/A |
| 2025-11-13 | Adage Capital Management, L.P. | 6.39% | SCHEDULE 13G/A |
| 2025-11-14 | Point72 Asset Management, L.P. | 2.6% | SCHEDULE 13G/A |
| 2025-11-14 | Perceptive Advisors LLC | 8.2% | SCHEDULE 13G/A |
| 2025-11-17 | Commodore Capital LP | 5.1% | SCHEDULE 13G |
| 2026-01-21 | BlackRock, Inc. | 7.1% | SCHEDULE 13G/A |
| 2026-01-30 | The Vanguard Group | 5.28% | SCHEDULE 13G |
| 2026-02-05 | Fmr LLC | 15% | SCHEDULE 13G/A |
| 2026-02-12 | Adage Capital Management, L.P. | 2.53% | SCHEDULE 13G/A |
| 2026-02-17 | TCG Crossover GP II, LLC | 5.7% | SCHEDULE 13G/A |
| 2026-03-26 | The Vanguard Group | 0% | SCHEDULE 13G/A |
| 2026-05-15 | Perceptive Advisors LLC | 7.5% | SCHEDULE 13G/A |
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Where this comes from
Anyone who comes to own more than 5% of a class of a listed company's voting shares has to tell the SEC. A holder who may seek to change or influence the company files Schedule 13D, and has to say in Item 4, "Purpose of Transaction", what it intends to do. A holder with no such intent, such as many index and passive funds, may file the shorter Schedule 13G. Both are amended when the stake changes, including when it falls below 5%.
Every row here is one of those filings, linked to the filing itself. Percentages and share counts are exactly as the holder filed them, for the holder the filing names; an amendment showing a lower figure is shown as filed. Item 4 text is quoted word for word. Where a 13D's Item 4 contains a sentence stating a definite intent to influence the company, that sentence is marked and quoted; the page does not describe the holder or its motives beyond the words it filed. Nothing here is investment advice.