As of November 10, 2026, Orchestra BioMed Holdings, Inc. is a publicly traded company (Nasdaq: OBIO). The largest holder reporting an active stake on Schedule 13D is RTW Investments, at 19.2%. No bankruptcy or receivership appears in its SEC Form 8-K filings. Passive holders reporting on Schedule 13G include Medtronic plc (17.8%), Perceptive Advisors (9.99%), Dana Lorenzo (5.5%) (Schedule 13D/A, April 29, 2026).
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Is Orchestra BioMed Holdings, Inc. a real, registered company?
- Orchestra BioMed Holdings, Inc. files with the SEC under CIK 1814114 (its SEC filings).
- Its shares are listed under the ticker OBIO on Nasdaq (SEC company record).
- Incorporated in Delaware; business address in New Hope, Pennsylvania, as its SEC filings state.
- Court and bankruptcy records: see Before you sign or pay below.
Before you sign or pay
- Court and bankruptcy: No federal court case or bankruptcy filing found under ORCHESTRA BIOMED HOLDINGS, INC. in our court records and SEC 8-K records (as of 2026-11-10).
- Ownership: 5%+ holders are reported on Schedule 13D or 13G; the latest names RTW Investments (filed 2026-04-29).
Who are Orchestra BioMed Holdings, Inc.'s owners and officers?
Orchestra BioMed Holdings, Inc.: incorporated in Delaware; business address in New Hope, Pennsylvania; industry Surgical & Medical Instruments & Apparatus (Schedule 13D/A, 2026-04-29).
| Report | Holder | Share |
|---|---|---|
| Schedule 13D/A, 2026-04-29 | Rtw Investments, LP | 19.2% |
| Schedule 13G/A, 2026-02-27 | Medtronic PLC | 17.8% |
| Schedule 13D/A, 2026-02-25 | Rtw Investments, LP | 19.7% |
| Schedule 13G, 2025-11-19 | Dana Lorenzo | 5.5% |
| Schedule 13G/A, 2025-11-14 | Perceptive Advisors LLC | 9.99% |
| Schedule 13D/A, 2025-08-06 | Rtw Investments, LP | 15.4% |
Questions about who owns Orchestra BioMed Holdings, Inc.
Who owns Orchestra BioMed Holdings, Inc.?
On this page, 4 holders' latest ownership filings report 5% or more of Orchestra BioMed Holdings, Inc.: Rtw Investments, LP (19.2%, Schedule 13D/A, filed 2026-04-29), Medtronic PLC (17.8%, Schedule 13G/A, filed 2026-02-27), Perceptive Advisors LLC (9.99%, Schedule 13G/A, filed 2025-11-14) and Dana Lorenzo (5.5%, Schedule 13G, filed 2025-11-19).
Who are the largest shareholders of Orchestra BioMed Holdings, Inc.?
By the share each holder's latest filing reports, the largest holders of Orchestra BioMed Holdings, Inc. on this page are Rtw Investments, LP (19.2%), Medtronic PLC (17.8%) and Perceptive Advisors LLC (9.99%).
When did Rtw Investments, LP buy into Orchestra BioMed Holdings, Inc.?
The filings give report dates, not purchase dates. The earliest filing from Rtw Investments, LP on this page is the Schedule 13D/A, filed 2025-08-06, reporting 15.4%; its latest, Schedule 13D/A filed 2026-04-29, reports 19.2%. That earliest filing is itself an amendment, which updates an earlier report.
Is this an audit or a full list?
Neither. The ownership list on this page covers only Schedule 13D and 13G filings, which holders make once they own 5% or more of a class of shares (an amendment can report a stake that has since fallen below 5%); 6 such filings are shown here. It is not an audit and not a full cap table: holders who never reached 5% are not listed, and a stake can change after its latest filing.
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Which insiders own Orchestra BioMed Holdings, Inc. shares?
Directors, officers and holders of 10% or more report their shares on Forms 3, 4 and 5. Each line is the latest such report, largest holding first.
- RTW Investments, a 10% owner: 9,556,063 shares (15.9% of shares outstanding), held indirectly (the form names the holder only in its footnotes), on a joint filing (Form 4, 2026-04-29).
- , a 10% owner: 9,556,063 shares (15.9% of shares outstanding), held indirectly (the form names the holder only in its footnotes), on a joint filing (Form 4, 2026-04-29).
- , a 10% owner: 5,292,556 shares (8.8% of shares outstanding), held indirectly (the form names the holder only in its footnotes), on a joint filing (Form 4, 2025-08-05).
- Perceptive Life Sciences Master Fund Ltd., a 10% owner: 5,292,556 shares (8.8% of shares outstanding), held indirectly (the form names the holder only in its footnotes), on a joint filing (Form 4, 2025-08-05).
- Perceptive Advisors, a 10% owner: 5,292,556 shares (8.8% of shares outstanding), held indirectly (the form names the holder only in its footnotes), on a joint filing (Form 4, 2025-08-05).
Shares outstanding: 60,105,049 as of 2026-08-06, from the company's latest SEC cover page.
How much has Orchestra BioMed Holdings, Inc. raised?
No fundraising or offering filing from Orchestra BioMed Holdings, Inc. is on file with us.
Keep reading
More on Orchestra BioMed Holdings, Inc. and the records around it.
Orchestra BioMed Holdings, Inc. elsewhere on the record
- 5%+ stake filings Apr 2026
Companies that share a holder
- Medtronic plc also filed stake reports on 2 other companies: Anteris Technologies Global Corp. (Jan 2026)
- Tasso Partners, LLC also filed stake reports on 2 other companies: PAVmed Inc. (Apr 2026), DarioHealth Corp. (Nov 2025)
- RTW Investments, LP also filed stake reports on 43 other companies: CG Oncology, Inc. (Aug 2026), iRhythm Holdings, Inc. (Aug 2026), Kailera Therapeutics, Inc. (Aug 2026)
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