Karyopharm Therapeutics Inc. has 30 Schedule 13D or 13G filings on record since 2025-07-16. 8 holders' latest filing reports 5% or more of common stock, $0.0001 par value. Each figure below is the holder's own, as filed, with the filing linked.
Holders
| Holder | Percent | Shares | Latest | Event date |
|---|---|---|---|---|
| RA Capital Management, L.P. | 9.9% | 2,302,504 | SCHEDULE 13G/A, 2026-08-14 | 2026-06-30 |
| Affinity Asset Advisors, LLC | 8.6% | 2,073,517 | SCHEDULE 13G/A, 2026-05-14 | 2026-03-31 |
| Adage Capital Management, L.P. | 6.78% | 1,536,736 | SCHEDULE 13G/A, 2026-08-12 | 2026-06-30 |
| T. Rowe Price Investment Management, Inc. | 6.6% | 1,539,147 | SCHEDULE 13G/A, 2026-06-05 | 2026-05-31 |
| The Goldman Sachs Group, Inc. | 6.3% | 1,429,198 | SCHEDULE 13G/A, 2026-08-11 | 2026-06-30 |
| Integrated Core Strategies (US) LLC | 5.7% | 1,297,297 | SCHEDULE 13G, 2026-09-04 | 2026-08-31 |
| Anders Hove | 5.7% | 1,284,221 | SCHEDULE 13G/A, 2026-09-25 | 2026-09-22 |
| BlackRock, Inc. | 5.6% | 1,266,084 | SCHEDULE 13G, 2026-07-28 | 2026-06-30 |
| J. Wood Capital Advisors LLC | 4.99% | 1,000,708 | SCHEDULE 13G/A, 2025-11-03 | 2025-10-14 |
| Jpmorgan Chase & Co. | 4.9% | 427,624 | SCHEDULE 13G/A, 2025-10-17 | 2025-09-30 |
| Highbridge Capital Management, LLC | 4.9% | 649,984 | SCHEDULE 13G/A, 2025-11-14 | 2025-09-30 |
| The Vanguard Group | 4.7% | 408,222 | SCHEDULE 13G/A, 2025-10-30 | 2025-09-30 |
| Opaleye Management Inc. | 2.67% | 619,089 | SCHEDULE 13G/A, 2026-05-11 | 2026-03-31 |
| Commodore Capital LP | 0% | 0 | SCHEDULE 13G/A, 2026-08-14 | |
| Ikarian Capital, LLC | 0% | 0 | SCHEDULE 13G, 2026-05-15 | 2026-03-31 |
Timeline
| Filed | Holder | Percent | Filing |
|---|---|---|---|
| 2025-07-16 | Jpmorgan Chase & Co. | 5.2% | SCHEDULE 13G |
| 2025-08-14 | T. Rowe Price Investment Management, Inc. | 8.4% | SCHEDULE 13G |
| 2025-10-17 | Jpmorgan Chase & Co. | 4.9% | SCHEDULE 13G/A |
| 2025-10-17 | Opaleye Management Inc. | 9.48% | SCHEDULE 13G |
| 2025-10-30 | The Vanguard Group | 4.7% | SCHEDULE 13G/A |
| 2025-11-03 | J. Wood Capital Advisors LLC | 4.99% | SCHEDULE 13G/A |
| 2025-11-07 | T. Rowe Price Investment Management, Inc. | 13.8% | SCHEDULE 13G/A |
| 2025-11-14 | Highbridge Capital Management, LLC | 4.9% | SCHEDULE 13G/A |
| 2026-01-29 | Affinity Asset Advisors, LLC | 8.6% | SCHEDULE 13G/A |
| 2026-02-10 | Millennium Management LLC | 5.5% | SCHEDULE 13G |
| 2026-02-12 | Adage Capital Management, L.P. | 2.38% | SCHEDULE 13G/A |
| 2026-02-17 | T. Rowe Price Investment Management, Inc. | 11.8% | SCHEDULE 13G/A |
| 2026-04-02 | RA Capital Management, L.P. | 9.9% | SCHEDULE 13G |
| 2026-04-02 | Commodore Capital LP | 9.9% | SCHEDULE 13G |
| 2026-04-13 | Millennium Management LLC | 2.3% | SCHEDULE 13G/A |
| 2026-05-11 | Opaleye Management Inc. | 2.67% | SCHEDULE 13G/A |
| 2026-05-12 | The Goldman Sachs Group, Inc. | 5.1% | SCHEDULE 13G |
| 2026-05-13 | Adage Capital Management, L.P. | 8.08% | SCHEDULE 13G |
| 2026-05-14 | Affinity Asset Advisors, LLC | 8.6% | SCHEDULE 13G/A |
| 2026-05-15 | Ikarian Capital, LLC | 0% | SCHEDULE 13G |
| 2026-05-15 | Anders Hove | 6.7% | SCHEDULE 13G |
| 2026-06-05 | T. Rowe Price Investment Management, Inc. | 6.6% | SCHEDULE 13G/A |
| 2026-07-28 | BlackRock, Inc. | 5.6% | SCHEDULE 13G |
| 2026-08-11 | The Goldman Sachs Group, Inc. | 6.3% | SCHEDULE 13G/A |
| 2026-08-12 | Adage Capital Management, L.P. | 6.78% | SCHEDULE 13G/A |
| 2026-08-14 | RA Capital Management, L.P. | 9.9% | SCHEDULE 13G/A |
| 2026-08-14 | Commodore Capital LP | 0% | SCHEDULE 13G/A |
| 2026-09-04 | Integrated Core Strategies (US) LLC | 5.7% | SCHEDULE 13G |
| 2026-09-25 | Anders Hove | 5.7% | SCHEDULE 13G/A |
| 2026-09-25 | Anders Hove | 5.7% | SCHEDULE 13G/A |
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Where this comes from
Anyone who comes to own more than 5% of a class of a listed company's voting shares has to tell the SEC. A holder who may seek to change or influence the company files Schedule 13D, and has to say in Item 4, "Purpose of Transaction", what it intends to do. A holder with no such intent, such as many index and passive funds, may file the shorter Schedule 13G. Both are amended when the stake changes, including when it falls below 5%.
Every row here is one of those filings, linked to the filing itself. Percentages and share counts are exactly as the holder filed them, for the holder the filing names; an amendment showing a lower figure is shown as filed. Item 4 text is quoted word for word. Where a 13D's Item 4 contains a sentence stating a definite intent to influence the company, that sentence is marked and quoted; the page does not describe the holder or its motives beyond the words it filed. Nothing here is investment advice.