About 57 employees are affected, according to Fulcrum Therapeutics, Inc.'s latest layoff filing, on June 4, 2026. As of November 6, 2026, Fulcrum Therapeutics, Inc. has reported this one exit or restructuring plan to the SEC on Form 8-K under Item 2.05. No WARN notice under its name is on file in the states covered here (Form 8-K, June 4, 2026).
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Fulcrum Therapeutics, Inc. reported 1 exit or restructuring plan on Form 8-K under Item 2.05, 1 of 1 stating how many employees or positions are affected. Each fact below is the filing's own sentence, quoted and linked. No WARN notice under this company's name is on file in the states covered here.
Did Fulcrum Therapeutics have layoffs in 2026? What its filings say
Fulcrum Therapeutics, Inc. (CIK 1680581) reported 1 exit or restructuring plan to the SEC on Form 8-K under Item 2.05. The sentences below are quoted from the filings as written.
Form 8-K filed 2026-06-04
Employees affected
The restructuring plan will reduce Fulcrum's workforce by approximately 85%, from 57 full-time employees to 9 full-time employees, and is expected to be substantially completed during the second quarter of 2026.
Expected charges
Fulcrum expects to incur aggregate charges of approximately $4.2 million in connection with the restructuring plan, consisting primarily of employee severance, employee benefits and related costs.
Also on the record for Fulcrum Therapeutics, Inc.
| Date | Record | Figure | Our page | Source |
|---|---|---|---|---|
| October 28, 2026 | Stake report, Schedule 13G/A, by BANK OF AMERICA CORP /DE/ | 1.5% of the class | 5%+ stakes | Source |
| October 27, 2026 | Stake report, Schedule 13G/A, by BlackRock Portfolio Management LLC | 8.1% of the class | 5%+ stakes | Source |
| August 14, 2026 | Stake report, Schedule 13G, by Nantahala Capital Management, LLC | 8.22% of the class | 5%+ stakes | Source |
| August 14, 2026 | Stake report, Schedule 13G/A, by Montanova Capital, LLC | 5.5% of the class | 5%+ stakes | Source |
| August 14, 2026 | Stake report, Schedule 13G/A, by RA Capital Management, L.P. | — | 5%+ stakes | Source |
| August 14, 2026 | Stake report, Schedule 13G/A, by TCG Crossover GP II, LLC | — | 5%+ stakes | Source |
| August 10, 2026 | Leadership change: Alan Musso appointed | — | Leadership changes | Source |
| August 3, 2026 | Stake report, Schedule 13G, by BANK OF AMERICA CORP /DE/ | 6.7% of the class | 5%+ stakes | Source |
| July 28, 2026 | Stake report, Schedule 13G/A, by BlackRock, Inc. | 7.2% of the class | 5%+ stakes | Source |
| July 17, 2026 | Stake report, Schedule 13G, by BlackRock Portfolio Management LLC | 6% of the class | 5%+ stakes | Source |
| July 15, 2026 | Stake report, Schedule 13G/A, by TANG CAPITAL MANAGEMENT, LLC | 10.4% of the class | 5%+ stakes | Source |
| June 25, 2026 | Stake report, Schedule 13G, by EcoR1 Capital, LLC | 9% of the class | 5%+ stakes | Source |
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More on Fulcrum Therapeutics, Inc. and the records around it.
Fulcrum Therapeutics, Inc. elsewhere on the record
- 5%+ stake filings Oct 2026
- Leadership changes Aug 2026
- Who owns it
Companies that share a holder
- EcoR1 Capital, LLC also filed stake reports on 20 other companies: Mereo BioPharma Group plc (Aug 2026), Alto Neuroscience, Inc. (Jul 2026), Eloxx Pharmaceuticals, Inc. (Jun 2026)
- TCG Crossover GP II, LLC also filed stake reports on 21 other companies: ALX Oncology Holdings Inc. (Aug 2026), First Tracks Biotherapeutics, Inc. (Aug 2026), LB Pharmaceuticals Inc. (Aug 2026)
- Montanova Capital, LLC also filed stake reports on 22 other companies: Veradermics, Inc (Aug 2026), Abeona Therapeutics Inc. (Aug 2026), InflaRx N.V. (Aug 2026)
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Public companies must also report to the SEC, on Form 8-K under Item 2.05, when they commit to an exit or restructuring plan that will cost them material charges, which is how most large layoffs and closures by listed companies are disclosed. Those filings are national, so they cover companies in every state. Each sentence shown from one is quoted exactly and linked to the filing; where a filing does not state a figure, none is shown.
Where this comes from
Employers covered by the federal WARN Act, and by the stricter laws some states add, must give written notice before a mass layoff or a site closure. The state labor department publishes those notices. Every row here is one of them, taken from that state's own published file and linked to it, so each figure can be checked at the source.
A notice states the employer, the location, the number of employees affected, and when the layoff or closure takes effect. It does not state a reason, and neither does this page. Where a company also appears in SEC filings under the same name and in the same state, its recorded fundraising is shown alongside, as a matter of record rather than as an explanation. New Jersey and Pennsylvania list a notice under the month it was posted or received, not the day, so their notices show a month. Tennessee gives the county rather than the city.
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