As of November 8, 2026, 4 holders' latest Schedule 13D or 13G filings report owning 5% or more of Alpha Cognition Inc. The largest reported stake is Opaleye Management Inc.'s, at 14.22%. 16 filings are on record since October 3, 2025 (Schedule 13G/A, July 24, 2026).
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Key facts
- · Reporting person: Manchester Management Company, LLC · Sole voting: 0 · Shared voting: 1,524,255 · Sole dispositive: 0 · Shared dispositive: 1,524,255 · SCHEDULE 13G, 2026-09-23
- · Reporting person: Opaleye Management Inc. · Sole voting: 0 · Shared voting: 3,095,193 · Sole dispositive: 0 · Shared dispositive: 3,095,193 · SCHEDULE 13G/A, 2026-07-24
- · Holder: Opaleye Management Inc. · Percent: 13.3% · SCHEDULE 13G/A
- · Holder: Opaleye Management Inc. · Percent: 12.03% · SCHEDULE 13G/A
- · Holder: James E. Besser · Percent: 4.9% · SCHEDULE 13G/A
Alpha Cognition Inc. has 16 Schedule 13D or 13G filings on record since 2025-10-03. 4 holders' latest filing reports 5% or more of common stock, no par value. Each figure below is the holder's own, as filed, with the filing linked.
Holders
| Holder | Percent | Shares | Latest | Event date |
|---|---|---|---|---|
| Opaleye Management Inc. | 14.22% | 3,095,193 | SCHEDULE 13G/A, 2026-07-24 | 2026-07-23 |
| AWM Investment Company, Inc. | 9.9% | 2,172,036 | SCHEDULE 13G/A, 2026-02-13 | 2025-12-31 |
| 7.4% | 1,639,255 | SCHEDULE 13G, 2026-09-23 | 2026-07-14 | |
| Funicular Funds, LP | 5.1% | 1,114,747 | SCHEDULE 13G, 2026-02-19 | 2026-02-11 |
| Ikarian Capital, LLC | 4.9% | 1,056,259 | SCHEDULE 13G/A, 2026-02-17 | 2025-12-31 |
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More on Alpha Cognition Inc. and the records around it.
Alpha Cognition Inc. elsewhere on the record
- Leadership changes Jun 2026
- Who owns it
Companies that share a holder
- Manchester Management Company, LLC also filed stake reports on 2 other companies: EUPRAXIA PHARMACEUTICALS INC. (Aug 2026), SANUWAVE Health, Inc. (Dec 2025)
- Funicular Funds, LP also filed stake reports on 10 other companies: AmpliTech Group, Inc. (Oct 2026), SYNLOGIC, INC. (Jul 2026), Rein Therapeutics, Inc. (May 2026)
- Opaleye Management Inc. also filed stake reports on 12 other companies: Codexis, Inc. (Nov 2026), Gossamer Bio, Inc. (Nov 2026), Pasithea Therapeutics Corp. (Nov 2026)
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Voting and dispositive power, as filed
| Reporting person | Sole voting | Shared voting | Sole dispositive | Shared dispositive | Filing |
|---|---|---|---|---|---|
| Opaleye Management Inc. | 0 | 3,095,193 | 0 | 3,095,193 | SCHEDULE 13G/A, 2026-07-24 |
| Opaleye, L.P. | 0 | 2,995,193 | 0 | 2,995,193 | SCHEDULE 13G/A, 2026-07-24 |
| James Silverman | 0 | 3,095,193 | 0 | 3,095,193 | SCHEDULE 13G/A, 2026-07-24 |
| Manchester Management Company, LLC | 0 | 1,524,255 | 0 | 1,524,255 | SCHEDULE 13G, 2026-09-23 |
| Manchester Management PR, LLC | 0 | 1,524,255 | 0 | 1,524,255 | SCHEDULE 13G, 2026-09-23 |
| Manchester Explorer, L.P. | 0 | 1,348,255 | 0 | 1,348,255 | SCHEDULE 13G, 2026-09-23 |
| James E. Besser | 115,000 | 1,524,255 | 115,000 | 1,524,255 | SCHEDULE 13G, 2026-09-23 |
| Morgan C. Frank | 45,000 | 1,348,255 | 45,000 | 1,348,255 | SCHEDULE 13G, 2026-09-23 |
The latest filing identifies Alpha Cognition Inc. by CUSIP 02074J501 and gives its principal executive office as 1452 Hughes Street, Ste. 200, Grapevine, TX 76051 (SCHEDULE 13G, 2026-09-23).
Timeline
| Filed | Holder | Percent | Filing |
|---|---|---|---|
| 2025-10-03 | Opaleye Management Inc. | 8.97% | SCHEDULE 13G |
| 2026-02-06 | Opaleye Management Inc. | 9.52% | SCHEDULE 13G |
| 2026-02-13 | AWM Investment Company, Inc. | 9.9% | SCHEDULE 13G/A |
| 2026-02-17 | Manchester Management Company, LLC | 5.1% | SCHEDULE 13G |
| 2026-02-17 | Ikarian Capital, LLC | 4.9% | SCHEDULE 13G/A |
| 2026-02-18 | Funicular Funds, LP | 4.9% | SCHEDULE 13G/A |
| 2026-02-19 | Funicular Funds, LP | 5.1% | SCHEDULE 13G |
| 2026-02-20 | Opaleye Management Inc. | 10.43% | SCHEDULE 13G/A |
| 2026-02-20 | Opaleye Management Inc. | 10.09% | SCHEDULE 13G/A |
| 2026-03-04 | Opaleye Management Inc. | 11% | SCHEDULE 13G/A |
| 2026-05-11 | Opaleye Management Inc. | 11.77% | SCHEDULE 13G/A |
| 2026-05-12 | James E. Besser | 4.9% | SCHEDULE 13G/A |
| 2026-05-22 | Opaleye Management Inc. | 12.03% | SCHEDULE 13G/A |
| 2026-06-29 | Opaleye Management Inc. | 13.3% | SCHEDULE 13G/A |
| 2026-07-24 | Opaleye Management Inc. | 14.22% | SCHEDULE 13G/A |
| 2026-09-23 | James E. Besser | 7.4% | SCHEDULE 13G |
Questions about who owns Alpha Cognition Inc.
Who owns Alpha Cognition Inc.?
On this page, 4 holders' latest ownership filings report 5% or more of Alpha Cognition Inc.: Opaleye Management Inc. (14.22%, Schedule 13G/A, filed 2026-07-24), AWM Investment Company, Inc. (9.9%, Schedule 13G/A, filed 2026-02-13), James E. Besser (7.4%, Schedule 13G, filed 2026-09-23) and Funicular Funds, LP (5.1%, Schedule 13G, filed 2026-02-19).
Who are the largest shareholders of Alpha Cognition Inc.?
By the share each holder's latest filing reports, the largest holders of Alpha Cognition Inc. on this page are Opaleye Management Inc. (14.22%), AWM Investment Company, Inc. (9.9%) and James E. Besser (7.4%).
When did Opaleye Management Inc. buy into Alpha Cognition Inc.?
The filings give report dates, not purchase dates. The earliest filing from Opaleye Management Inc. on this page is the Schedule 13G, filed 2025-10-03, reporting 8.97%; its latest, Schedule 13G/A filed 2026-07-24, reports 14.22%.
Is this an audit or a full list?
Neither. The ownership list on this page covers only Schedule 13D and 13G filings, which holders make once they own 5% or more of a class of shares (an amendment can report a stake that has since fallen below 5%); 16 such filings are shown here. It is not an audit and not a full cap table: holders who never reached 5% are not listed, and a stake can change after its latest filing.
Also on the record for Alpha Cognition Inc.
| Date | Record | Figure | Our page | Source |
|---|---|---|---|---|
| June 23, 2026 | Leadership change filing (Form 8-K, Item 5.02) | — | Leadership changes | Source |
| May 1, 2026 | Leadership change filing (Form 8-K, Item 5.02) | — | Leadership changes | Source |
| April 20, 2026 | Leadership change: Bethany Sensenig appointed, Director | — | Leadership changes | Source |
| November 18, 2024 | Form D, private offering | — | Form D page | Source |
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Where this comes from
Anyone who comes to own more than 5% of a class of a listed company's voting shares has to tell the SEC. A holder who may seek to change or influence the company files Schedule 13D, and has to say in Item 4, "Purpose of Transaction", what it intends to do. A holder with no such intent, such as many index and passive funds, may file the shorter Schedule 13G. Both are amended when the stake changes, including when it falls below 5%.
Every row here is one of those filings, linked to the filing itself. Percentages and share counts are exactly as the holder filed them, for the holder the filing names; an amendment showing a lower figure is shown as filed. Item 4 text is quoted word for word. Where a 13D's Item 4 contains a sentence stating a definite intent to influence the company, that sentence is marked and quoted; the page does not describe the holder or its motives beyond the words it filed. Nothing here is investment advice.