As of November 6, 2026, 3 holders' latest Schedule 13D or 13G filings report owning 5% or more of Acadia Pharmaceuticals Inc. The largest reported stake is Baker Bros. Advisors LP's, at 25.4%. 5 filings are on record since November 14, 2025 (Schedule 13D/A, February 26, 2026).
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Key facts
- · Reporting person: State Street Corporation · Sole voting: 0 · Shared voting: 8,679,785 · Sole dispositive: 0 · Shared dispositive: 9,076,212 · SCHEDULE 13G, 2026-08-07
- · Reporting person: Vanguard Portfolio Management · Sole voting: 109,362 · Shared voting: 0 · Sole dispositive: 8,781,007 · Shared dispositive: 0 · SCHEDULE 13G, 2026-04-28
- · Reporting person: The Vanguard Group · Sole voting: 0 · Shared voting: 0 · Sole dispositive: 0 · Shared dispositive: 0 · SCHEDULE 13G/A, 2026-03-26
- · Reporting person: Baker Bros. Advisors LP · Sole voting: 43,151,054 · Shared voting: 0 · Sole dispositive: 43,151,054 · Shared dispositive: 0 · SCHEDULE 13D/A, 2026-02-26
- · Holder: RTW Investments, LP · Percent: 4.2% · SCHEDULE 13G/A
Acadia Pharmaceuticals Inc has 5 Schedule 13D or 13G filings on record since 2025-11-14. 3 holders' latest filing reports 5% or more of common stock. Each figure below is the holder's own, as filed, with the filing linked.
Holders
| Holder | Percent | Shares | Latest | Event date |
|---|---|---|---|---|
| Baker Bros. Advisors LP | 25.4% | 43,151,054 | SCHEDULE 13D/A, 2026-02-26 | 2026-02-24 |
| State Street Corporation | 5.3% | 9,076,212 | SCHEDULE 13G, 2026-08-07 | 2026-06-30 |
| Vanguard Portfolio Management | 5.15% | 8,781,007 | SCHEDULE 13G, 2026-04-28 | 2026-03-31 |
| RTW Investments, LP | 4.2% | 7,144,524 | SCHEDULE 13G/A, 2025-11-14 | 2025-09-30 |
| The Vanguard Group | 0% | 0 | SCHEDULE 13G/A, 2026-03-26 | 2026-03-13 |
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Keep reading
More on Acadia Pharmaceuticals Inc and the records around it.
Acadia Pharmaceuticals Inc elsewhere on the record
- Leadership changes May 2026
- Who owns it
Companies that share a holder
- Baker Bros. Advisors LP also filed stake reports on 25 other companies: Madrigal Pharmaceuticals, Inc. (Nov 2026), Kodiak Sciences Inc. (Sep 2026), BeOne Medicines Ltd. (Sep 2026)
- RTW Investments, LP also filed stake reports on 43 other companies: CG Oncology, Inc. (Aug 2026), iRhythm Holdings, Inc. (Aug 2026), Kailera Therapeutics, Inc. (Aug 2026)
- STATE STREET CORPORATION also filed stake reports on 343 other companies: TRADE DESK INC/THE (Oct 2026), CENTRUS ENERGY CORP (Sep 2026), ALLEGION PLC (Aug 2026)
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What the Full Report on Acadia Pharmaceuticals Inc covers
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Voting and dispositive power, as filed
| Reporting person | Sole voting | Shared voting | Sole dispositive | Shared dispositive | Filing |
|---|---|---|---|---|---|
| Baker Bros. Advisors LP | 43,151,054 | 0 | 43,151,054 | 0 | SCHEDULE 13D/A, 2026-02-26 |
| Baker Bros. Advisors (GP) LLC | 43,151,054 | 0 | 43,151,054 | 0 | SCHEDULE 13D/A, 2026-02-26 |
| Julian C. Baker | 43,294,373 | 0 | 43,294,373 | 0 | SCHEDULE 13D/A, 2026-02-26 |
| Felix J. Baker | 43,294,373 | 0 | 43,294,373 | 0 | SCHEDULE 13D/A, 2026-02-26 |
| Fbb3 LLC | 40,443 | 0 | 40,443 | 0 | SCHEDULE 13D/A, 2026-02-26 |
| State Street Corporation | 0 | 8,679,785 | 0 | 9,076,212 | SCHEDULE 13G, 2026-08-07 |
| Vanguard Portfolio Management | 109,362 | 0 | 8,781,007 | 0 | SCHEDULE 13G, 2026-04-28 |
| The Vanguard Group | 0 | 0 | 0 | 0 | SCHEDULE 13G/A, 2026-03-26 |
The latest filing identifies Acadia Pharmaceuticals Inc by CUSIP 004225108 and gives its principal executive office as 12830 EL CAMINO REAL SUITE 400, SAN DIEGO, CA 92130 (SCHEDULE 13G, 2026-08-07).
Source of funds (Item 3)
Item 3 of Amendment No. 17 is supplemented and amended, as the case may be, as follows: The Reporting Persons may in the ordinary course of business hold securities in margin accounts maintained for the Funds with prime brokers, which extend margin credit as and when required, subject to applicable margin regulations, stock exchange rules and such firms' credit policies. Positions in securities may be pledged as collateral security for the repayment of debit balances in such accounts.Baker Bros. Advisors LP, SCHEDULE 13D/A, 2026-02-26
Timeline
| Filed | Holder | Percent | Filing |
|---|---|---|---|
| 2025-11-14 | RTW Investments, LP | 4.2% | SCHEDULE 13G/A |
| 2026-02-26 | Baker Bros. Advisors LP | 25.4% | SCHEDULE 13D/A |
| 2026-03-26 | The Vanguard Group | 0% | SCHEDULE 13G/A |
| 2026-04-28 | Vanguard Portfolio Management | 5.15% | SCHEDULE 13G |
| 2026-08-07 | State Street Corporation | 5.3% | SCHEDULE 13G |
Questions about who owns Acadia Pharmaceuticals Inc
Who owns Acadia Pharmaceuticals Inc?
On this page, 3 holders' latest ownership filings report 5% or more of Acadia Pharmaceuticals Inc: Baker Bros. Advisors LP (25.4%, Schedule 13D/A, filed 2026-02-26), State Street Corporation (5.3%, Schedule 13G, filed 2026-08-07) and Vanguard Portfolio Management (5.15%, Schedule 13G, filed 2026-04-28).
Who are the largest shareholders of Acadia Pharmaceuticals Inc?
By the share each holder's latest filing reports, the largest holders of Acadia Pharmaceuticals Inc on this page are Baker Bros. Advisors LP (25.4%), State Street Corporation (5.3%) and Vanguard Portfolio Management (5.15%).
When did Baker Bros. Advisors LP buy into Acadia Pharmaceuticals Inc?
The filings give report dates, not purchase dates. The earliest filing from Baker Bros. Advisors LP on this page is the Schedule 13D/A, filed 2026-02-26, reporting 25.4%. That earliest filing is itself an amendment, which updates an earlier report.
Is this an audit or a full list?
Neither. The ownership list on this page covers only Schedule 13D and 13G filings, which holders make once they own 5% or more of a class of shares (an amendment can report a stake that has since fallen below 5%); 5 such filings are shown here. It is not an audit and not a full cap table: holders who never reached 5% are not listed, and a stake can change after its latest filing.
Also on the record for Acadia Pharmaceuticals Inc
| Date | Record | Figure | Our page | Source |
|---|---|---|---|---|
| October 23, 2026 | Leadership change filing (Form 8-K, Item 5.02) | — | Leadership changes | Source |
| May 1, 2026 | Leadership change: Z. Thompson departs | — | Leadership changes | Source |
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Where this comes from
Anyone who comes to own more than 5% of a class of a listed company's voting shares has to tell the SEC. A holder who may seek to change or influence the company files Schedule 13D, and has to say in Item 4, "Purpose of Transaction", what it intends to do. A holder with no such intent, such as many index and passive funds, may file the shorter Schedule 13G. Both are amended when the stake changes, including when it falls below 5%.
Every row here is one of those filings, linked to the filing itself. Percentages and share counts are exactly as the holder filed them, for the holder the filing names; an amendment showing a lower figure is shown as filed. Item 4 text is quoted word for word. Where a 13D's Item 4 contains a sentence stating a definite intent to influence the company, that sentence is marked and quoted; the page does not describe the holder or its motives beyond the words it filed. Nothing here is investment advice.