Metsera, Inc.: 5%+ holders

As of November 8, 2026, one holder's latest Schedule 13D or 13G filing report owning 5% or more of Metsera, Inc. The largest reported stake is The Vanguard Group's, at 5.53%. 6 filings are on record since October 31, 2025 (Schedule 13G, October 31, 2025).

ARCH Venture Fund XII, L.P. also filed stake reports on 5 other companies ↓

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Key facts

• Filing 2026-02-17 · Reporting person: Janus Henderson Group Plc · Sole voting: 0 · Shared voting: 3,242,849 · Sole dispositive: 0 · Shared dispositive: 3,242,849 · SCHEDULE 13G/A, 2026-02-17
• Filing 2025-11-17 · Reporting person: Fmr LLC · Sole voting: 0 · Shared voting: 0 · Sole dispositive: 0 · Shared dispositive: 0 · SCHEDULE 13G/A, 2025-11-17
• Filing 2025-11-14 · Reporting person: ARCH Venture Fund XII, L.P. · Sole voting: 0 · Shared voting: 0 · Sole dispositive: 0 · Shared dispositive: 0 · SCHEDULE 13D/A, 2025-11-14
• Filed 2025-11-14 · Holder: Janus Henderson Group Plc · Percent: 5.1% · SCHEDULE 13G
• Event date 2025-11-13 · Holder: Population Health Partners, L.P. · Percent: 0% · Shares: 0 · SCHEDULE 13G/A

Metsera, Inc. has 6 Schedule 13D or 13G filings on record since 2025-10-31. 1 holder's latest filing reports 5% or more of common stock. Each figure below is the holder's own, as filed, with the filing linked.

Holders

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More on Metsera, Inc. and the records around it.

Metsera, Inc. elsewhere on the record

• Who owns it

Companies that share a holder

• ARCH Venture Fund XII, L.P. also filed stake reports on 5 other companies: City Therapeutics, Inc. (Oct 2026), Parabilis Medicines, Inc. (Aug 2026), Seaport Therapeutics, Inc. (May 2026)
• JANUS HENDERSON GROUP PLC also filed stake reports on 104 other companies: SURGERY PARTNERS, INC. (Nov 2026), EYEPOINT, INC. (Sep 2026), TELEFLEX INCORPORATED (Sep 2026)
• FMR LLC also filed stake reports on 761 other companies: ASPEN NEUROSCIENCE INC (Nov 2026), AVALO THERAPEUTICS INC (Nov 2026), BRAZE INC (Nov 2026)

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What the Full Report on Metsera, Inc. covers

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3. What They Do, And How The Money Works

4. Who Runs It, And How To Reach Them

5. The Money: Funding, Valuation, Runway

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7. Warning Bells

8. Sources

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Voting and dispositive power, as filed

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The latest filing names Metsera, Inc., with its principal executive office as 3 WORLD TRADE CENTER, 175 GREENWICH STREET, NEW YORK, NY 10007 (SCHEDULE 13G/A, 2026-02-17).

Timeline

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Questions about who owns Metsera, Inc.

Who owns Metsera, Inc.?

On this page, one holder's latest ownership filing reports 5% or more of Metsera, Inc.: The Vanguard Group (5.53%, Schedule 13G, filed 2025-10-31).

When did The Vanguard Group buy into Metsera, Inc.?

The filings give report dates, not purchase dates. The earliest filing from The Vanguard Group on this page is the Schedule 13G, filed 2025-10-31, reporting 5.53%.

Is this an audit or a full list?

Neither. The ownership list on this page covers only Schedule 13D and 13G filings, which holders make once they own 5% or more of a class of shares (an amendment can report a stake that has since fallen below 5%); 6 such filings are shown here. It is not an audit and not a full cap table: holders who never reached 5% are not listed, and a stake can change after its latest filing.

Also on the record for Metsera, Inc.

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Where this comes from

Anyone who comes to own more than 5% of a class of a listed company's voting shares has to tell the SEC. A holder who may seek to change or influence the company files Schedule 13D, and has to say in Item 4, "Purpose of Transaction", what it intends to do. A holder with no such intent, such as many index and passive funds, may file the shorter Schedule 13G. Both are amended when the stake changes, including when it falls below 5%.

Every row here is one of those filings, linked to the filing itself. Percentages and share counts are exactly as the holder filed them, for the holder the filing names; an amendment showing a lower figure is shown as filed. Item 4 text is quoted word for word. Where a 13D's Item 4 contains a sentence stating a definite intent to influence the company, that sentence is marked and quoted; the page does not describe the holder or its motives beyond the words it filed. Nothing here is investment advice.

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