Ultragenyx Pharmaceutical Inc.'s latest layoff filing, on November 3, 2026, states a cut of about 20% of its workforce. As of November 6, 2026, it has reported 2 exit or restructuring plans to the SEC on Form 8-K under Item 2.05. No WARN notice under its name is on file in the states covered here (Form 8-K, November 3, 2026).
Ultragenyx Pharmaceutical Inc. announced layoffs on Nov 3. 12 companies announced layoffs this week.
Companies cutting jobs this week. Before you unlock: the company, the number of employees and what is inside. After: every way we found to reach the company. No individual is named in a layoff.
| Artiva Biotherapeutics, Inc. | announced layoffs | |
| Eos Energy Enterprises, Inc. | announced layoffs | |
| SOUNDHOUND AI, INC. | announced layoffs | |
| Portillo's Inc. | announced layoffs | |
| Acumen Pharmaceuticals, Inc. | announced layoffs of about 52 employees |
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Ultragenyx Pharmaceutical Inc. reported 2 exit or restructuring plans on Form 8-K under Item 2.05, 1 of 2 stating how many employees or positions are affected. Each fact below is the filing's own sentence, quoted and linked. No WARN notice under this company's name is on file in the states covered here.
Did Ultragenyx Pharmaceutical have layoffs in 2026? What its filings say
Ultragenyx Pharmaceutical Inc. (CIK 1515673) reported 2 exit or restructuring plans to the SEC on Form 8-K under Item 2.05. The sentences below are quoted from the filings as written.
Form 8-K filed 2026-11-03
Share of workforce
As part of the Restructuring, the Company is implementing a workforce reduction of approximately 20% of its employees (the "RIF").
Expected charges
The Company estimates that it will incur approximately $25 million in total restructuring and restructuring-related charges, consisting primarily of employee severance payments and other employee-related costs.
Timing
The Company communicated the RIF on November 3, 2026 and expects the RIF to be substantially completed by the end of 2026.
Form 8-K filed 2026-02-12
Employees affected
As part of the Restructuring, the Company is implementing a 10% workforce reduction of approximately 130 employees across the Company (the "RIF").
Expected charges
The Company estimates that it will incur approximately $50 million in total restructuring and restructuring-related charges, consisting primarily of (i) approximately $10 million in total for employee severance payments and other employee-related costs and (ii) approximately $40 million in total for charges related to the termination of UX143 manufacturing agreements and other related activities.
Timing
The Company began notifying affected employees on February 12, 2026, and expects this RIF to be substantially completed in the first half of 2026.
Also on the record for Ultragenyx Pharmaceutical Inc.
| Date | Record | Figure | Our page | Source |
|---|---|---|---|---|
| October 30, 2026 | Stake report, Schedule 13G/A, by Vanguard Portfolio Management | 8.6% of the class | 5%+ stakes | Source |
| October 20, 2026 | Stake report, Schedule 13G, by Madison Avenue International LP | 6.4% of the class | 5%+ stakes | Source |
| August 14, 2026 | Stake report, Schedule 13G, by RTW Investments, LP | 7.9% of the class | 5%+ stakes | Source |
| August 13, 2026 | Stake report, Schedule 13G, by AQR Capital Management, LLC | 6.66% of the class | 5%+ stakes | Source |
| August 7, 2026 | Stake report, Schedule 13G, by STATE STREET CORPORATION | 6.3% of the class | 5%+ stakes | Source |
| July 31, 2026 | Stake report, Schedule 13G, by Vanguard Capital Management | 5.13% of the class | 5%+ stakes | Source |
| July 31, 2026 | Stake report, Schedule 13G/A, by Vanguard Portfolio Management | 6.95% of the class | 5%+ stakes | Source |
| July 30, 2026 | Stake report, Schedule 13G/A, by BlackRock, Inc. | 8.3% of the class | 5%+ stakes | Source |
| May 12, 2026 | Stake report, Schedule 13G, by STATE STREET CORPORATION | 5.1% of the class | 5%+ stakes | Source |
| April 29, 2026 | Stake report, Schedule 13G, by Vanguard Portfolio Management | 5.5% of the class | 5%+ stakes | Source |
| March 27, 2026 | Stake report, Schedule 13G/A, by The Vanguard Group | — | 5%+ stakes | Source |
| February 5, 2026 | Stake report, Schedule 13G/A, by FMR LLC | 3.5% of the class | 5%+ stakes | Source |
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More on Ultragenyx Pharmaceutical Inc. and the records around it.
Ultragenyx Pharmaceutical Inc. elsewhere on the record
- 5%+ stake filings Oct 2026
- Who owns it
Companies that share a holder
- Madison Avenue International LP also filed stake reports on 11 other companies: Graham Holdings Co (Aug 2026), STAAR SURGICAL CO (Aug 2026), Theravance Biopharma, Inc. (Aug 2026)
- RTW Investments, LP also filed stake reports on 43 other companies: CG Oncology, Inc. (Aug 2026), iRhythm Holdings, Inc. (Aug 2026), Kailera Therapeutics, Inc. (Aug 2026)
- AQR Capital Management, LLC also filed stake reports on 190 other companies: Bold Eagle Acquisition Corp. (Nov 2026), Centurion Acquisition Corp. (Aug 2026), FG Merger II Corp. n/k/a BOXABL Inc. (Aug 2026)
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Public companies must also report to the SEC, on Form 8-K under Item 2.05, when they commit to an exit or restructuring plan that will cost them material charges, which is how most large layoffs and closures by listed companies are disclosed. Those filings are national, so they cover companies in every state. Each sentence shown from one is quoted exactly and linked to the filing; where a filing does not state a figure, none is shown.
Where this comes from
Employers covered by the federal WARN Act, and by the stricter laws some states add, must give written notice before a mass layoff or a site closure. The state labor department publishes those notices. Every row here is one of them, taken from that state's own published file and linked to it, so each figure can be checked at the source.
A notice states the employer, the location, the number of employees affected, and when the layoff or closure takes effect. It does not state a reason, and neither does this page. Where a company also appears in SEC filings under the same name and in the same state, its recorded fundraising is shown alongside, as a matter of record rather than as an explanation. New Jersey and Pennsylvania list a notice under the month it was posted or received, not the day, so their notices show a month. Tennessee gives the county rather than the city.
Related
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- Eos Energy Enterprises, Inc.: 1 SEC filing, Nov 2026 layoff notice within 90 days (2026-11-05)
- Comcast: 902 jobs, Oct 2026 layoff notice within 90 days (2026-10-29)
- Endeavors: 124 jobs, FL and more, Oct 2026 layoff notice within 90 days (2026-10-29)
- Davey Tree Surgery Company: 368 jobs, Oct 2026 layoff notice within 90 days (2026-10-29)
Who owns Ultragenyx Pharmaceutical Inc? Owners, funding and legal record
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