Department of Health and Human Services, through National Institutes of Health, awarded Greenmark Biomedical Inc of East Lansing, MI $294,632 under the SBIR program (Phase II), with work starting 2025-04-03 and running to 2027-04-02. It is one of 2 SBIR and STTR awards Greenmark Biomedical Inc received in the last two years, $565,226 in all. Each figure links to the federal record.
The award
| Recipient | Greenmark Biomedical Inc (East Lansing, MI) |
|---|---|
| Awarding agency | Department of Health and Human Services |
| Awarding office | National Institutes of Health |
| Phase | Phase II |
| Amount obligated | $294,632 |
| Period of performance starts | 2025-04-03 |
| Period of performance ends | 2027-04-02 |
| Award number | R43DE034324 (grant, CFDA 93.121) |
| Assistance listing | 93.121, Oral Diseases and Disorders Research |
| Signed | 2025-03-27 |
| Recipient registry id (UEI) | C18FULMF7G73 |
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What it is for
Improving caries diagnosis with targeted nanoparticle-enhanced ai-assisted intraoral imaging - abstract: This project responds to the need identified by nidcr to develop improved methods to detect, monitor, and predict p
Funding actions on this award
| Date | Action | Modification | Amount |
|---|---|---|---|
| 2026-03-10 | Revision | 000 | $0 |
| 2025-03-27 | New | 000 | $294,632 |
Improving caries diagnosis with targeted nanoparticle-enhanced ai-assisted intraoral imaging - abstract: This project responds to the need identified by nidcr to develop improved methods to detect, monitor, and predict progression of dental caries (tooth decay) to improve human health. Worldwide, caries is the most common chronic disease affecting almost everyone. Dental disease is major cause of economic and social loss and leads to complications including pain, tooth loss and even death. For over a century, caries diagnosis has been performed visually and using a dental explorer, but early caries lesions are missed, and the explorer can cause cavitation. Like the world at large, dentistry is entering the era of artificial intelligence (AI), with some of the first applications to help dentists analyze x-rays. While radiographs identify more advanced decay, they lack resolution to identify early disease. Newer methods for caries diagnosis show little benefit over visual/tactile exam and incur greater cost to dentist and patient. None of these can distinguish between active and inactive carious lesions, a critical need in modern dentistry, and a requirement for disease monitoring. With SBIR funding (grant 5r44de027903-03), we have successfully developed a clinically validated mouth rinse that uses targeted fluorescent biopolymer nanoparticles to illuminate early active caries le ...
From the federal award record.
Other SBIR and STTR awards to Greenmark Biomedical Inc
| Starts | Agency | Program | Amount | Project |
|---|---|---|---|---|
| 2025-09-01 | Department of Health and Human Services | SBIR Phase I | $270,594 | Restoration of non-cavitated carious lesions in enamel using nano-fluorapatite particles - (record) |
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The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs set aside part of federal research budgets for small companies. Agencies award them in phases: Phase I tests whether an idea is feasible, Phase II funds development, and Phase III is follow-on work paid for outside the set-aside. STTR awards also require a research institution as a partner.
Every figure on this page is taken from the award's own federal record, linked beside it, as it stood when the page was built: the recipient, its address, the awarding agency and office, the amount obligated so far, the dates and the description. Phase and program are shown as the award's own description states them. The amount can grow later if the agency adds funding to the same award.