Department of Health and Human Services, through National Institutes of Health, awarded Cnd Life Sciences, Inc. of Scottsdale, AZ $2,289,462 under the SBIR program (Phase II), with work starting 2025-09-05 and running to 2028-08-31. It is the only SBIR or STTR award to Cnd Life Sciences, Inc. in the last two years. Each figure links to the federal record.
The award
| Recipient | Cnd Life Sciences, Inc. (Scottsdale, AZ) |
|---|---|
| Awarding agency | Department of Health and Human Services |
| Awarding office | National Institutes of Health |
| Phase | Phase II |
| Amount obligated | $2,289,462 |
| Period of performance starts | 2025-09-05 |
| Period of performance ends | 2028-08-31 |
| Award number | R44NS143486 (grant, CFDA 93.853) |
| Assistance listing | 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Place of performance | Scottsdale, Maricopa County, AZ |
| Signed | 2025-08-27 |
| Recipient registry id (UEI) | N8BNGXXEBP75 |
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What it is for
Analysis of cutaneous phosphorylated alpha-synuclein to identify patients at risk of progressing from essential tremor to parkinson's disease - project summary—in this direct-to-Phase II SBIR, cnd life sciences proposes
Funding actions on this award
| Date | Action | Modification | Amount |
|---|---|---|---|
| 2026-09-07 | Continuation | 000 | $1,012,800 |
| 2025-09-25 | Revision | 001 | $0 |
| 2025-08-27 | New | 000 | $1,276,662 |
Analysis of cutaneous phosphorylated alpha-synuclein to identify patients at risk of progressing from essential tremor to parkinson's disease - project summary—in this direct-to-Phase II SBIR, cnd life sciences proposes to 1) advance the development of a test to identify patients with essential tremor (et) who have deposits of phosphorylated a- synuclein (p-syn), a pathological hallmark of parkinson’s disease (pd), and 2) determine whether the test can predict which patients will phenoconvert to pd. Et is the most common movement disorder, affecting more than 5% of people over 60 and ~ 20% of people over 80. Each year, ~ 1% of patients with et develop pd—a rate almost 10 times higher than in older adults without et. Because the treatments and clinical course of et and pd differ substantially, there is a pressing need to identify patients who are at risk for phenoconversion from et to pd. In pd, progressive deposition of p-syn in the central and peripheral nervous systems is associated with a progressive degeneration of nerve fibers and loss of motor functions. Recent post-mortem analyses showed that p-syn is present in the brains of about 25% of patients with et, and ~ 80% of these p-syn-positive individuals exhibited “soft” neurological features of pd prior to death. Unfortunately, the current confirmatory test for pd (i.e., dat scan) is insensitive early in the disease course ...
From the federal award record.
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The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs set aside part of federal research budgets for small companies. Agencies award them in phases: Phase I tests whether an idea is feasible, Phase II funds development, and Phase III is follow-on work paid for outside the set-aside. STTR awards also require a research institution as a partner.
Every figure on this page is taken from the award's own federal record, linked beside it, as it stood when the page was built: the recipient, its address, the awarding agency and office, the amount obligated so far, the dates and the description. Phase and program are shown as the award's own description states them. The amount can grow later if the agency adds funding to the same award.