As of November 10, 2026, 3 holders' latest Schedule 13D or 13G filings report owning 5% or more of Personalis, Inc. The largest reported stake is Tempus AI, Inc.'s, at 12.6%. 11 filings are on record since September 12, 2025 (Schedule 13D/A, July 21, 2026).
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Key facts
- · Reporting person: Ameriprise Financial, Inc. · Sole voting: 0 · Shared voting: 6,054,599 · Sole dispositive: 0 · Shared dispositive: 6,086,315 · SCHEDULE 13G/A, 2026-08-14
- · Reporting person: Deep Track Capital, LP · Sole voting: 0 · Shared voting: 4,000,000 · Sole dispositive: 0 · Shared dispositive: 4,000,000 · SCHEDULE 13G/A, 2026-08-14
- · Reporting person: BlackRock, Inc. · Sole voting: 6,051,493 · Shared voting: 0 · Sole dispositive: 6,169,729 · Shared dispositive: 0 · SCHEDULE 13G, 2026-07-29
- · Reporting person: Tempus AI, Inc. · Sole voting: 0 · Shared voting: 13,039,067 · Sole dispositive: 0 · Shared dispositive: 13,039,067 · SCHEDULE 13D/A, 2026-07-21
- · Reporting person: Lightspeed Venture Partners Select IV, L.P. · Shared voting: 2,084,240 · Shared dispositive: 2,084,240 · SCHEDULE 13D/A, 2026-06-10
Personalis, Inc. has 11 Schedule 13D or 13G filings on record since 2025-09-12. 3 holders' latest filing reports 5% or more of common stock. Each figure below is the holder's own, as filed, with the filing linked.
Holders
| Holder | Percent | Shares | Latest | Event date |
|---|---|---|---|---|
| Tempus AI, Inc. | 12.6% | 13,039,067 | SCHEDULE 13D/A, 2026-07-21 | 2026-07-19 |
| BlackRock, Inc. | 5.9% | 6,169,729 | SCHEDULE 13G, 2026-07-29 | 2026-06-30 |
| Ameriprise Financial, Inc. | 5.8% | 6,086,315 | SCHEDULE 13G/A, 2026-08-14 | 2026-06-30 |
| T. Rowe Price Investment Management, Inc. | 4.5% | 4,758,091 | SCHEDULE 13G/A, 2026-04-08 | 2026-03-31 |
| Deep Track Capital, LP | 3.82% | 4,000,000 | SCHEDULE 13G/A, 2026-08-14 | 2026-06-30 |
| 3.8% | 3,416,720 | SCHEDULE 13G/A, 2026-01-29 | 2025-12-31 | |
| Lightspeed Venture Partners Select IV, L.P. | 2% | 2,084,240 | SCHEDULE 13D/A, 2026-06-10 | 2026-06-08 |
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More on Personalis, Inc. and the records around it.
Personalis, Inc. elsewhere on the record
Companies that share a holder
- Orin Hirschman also filed stake reports on 46 other companies: ASPEN AEROGELS, INC. (Oct 2026), Bionano Genomics, Inc. (Oct 2026), FENNEC PHARMACEUTICALS INC. (Oct 2026)
- Deep Track Capital, LP also filed stake reports on 59 other companies: Alector, Inc. (Oct 2026), TCGX Acquisition Corp. II (Oct 2026), Frazier Life Sciences Acquisition Corp. II (Oct 2026)
- Ameriprise Financial, Inc. also filed stake reports on 65 other companies: Universal Electronics Inc. (Sep 2026), America's Car-Mart, Inc. (Aug 2026), Ampco-Pittsburgh Corporation (Aug 2026)
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Voting and dispositive power, as filed
| Reporting person | Sole voting | Shared voting | Sole dispositive | Shared dispositive | Filing |
|---|---|---|---|---|---|
| Tempus AI, Inc. | 0 | 13,039,067 | 0 | 13,039,067 | SCHEDULE 13D/A, 2026-07-21 |
| Eric Lefkofsky | 150,000 | 13,039,067 | 150,000 | 13,039,067 | SCHEDULE 13D/A, 2026-07-21 |
| BlackRock, Inc. | 6,051,493 | 0 | 6,169,729 | 0 | SCHEDULE 13G, 2026-07-29 |
| Ameriprise Financial, Inc. | 0 | 6,054,599 | 0 | 6,086,315 | SCHEDULE 13G/A, 2026-08-14 |
| Deep Track Capital, LP | 0 | 4,000,000 | 0 | 4,000,000 | SCHEDULE 13G/A, 2026-08-14 |
| Deep Track Biotechnology Master Fund, Ltd. | 0 | 4,000,000 | 0 | 4,000,000 | SCHEDULE 13G/A, 2026-08-14 |
| David Kroin | 0 | 4,000,000 | 0 | 4,000,000 | SCHEDULE 13G/A, 2026-08-14 |
| Lightspeed Venture Partners Select IV, L.P. | — | 2,084,240 | — | 2,084,240 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed General Partner Select IV, L.P. | 0 | 2,084,240 | 0 | 2,084,240 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed Ultimate General Partner Select IV, L.L.C. | 0 | 2,084,240 | 0 | 2,084,240 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed Venture Partners Select, L.P. | 0 | 1,958,726 | 0 | 1,958,726 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed General Partner Select, L.P. | 0 | 1,958,726 | 0 | 1,958,726 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed Ultimate General Partner Select, Ltd. | 0 | 1,958,726 | 0 | 1,958,726 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed Venture Partners VIII, L.P. | 0 | 2,058,884 | 0 | 2,058,884 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed General Partner VIII, L.P. | 0 | 2,058,884 | 0 | 2,058,884 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed Ultimate General Partner VIII, Ltd. | 0 | 2,058,884 | 0 | 2,058,884 | SCHEDULE 13D/A, 2026-06-10 |
| LSVP VIII Trust | 0 | 2,058,884 | 0 | 2,058,884 | SCHEDULE 13D/A, 2026-06-10 |
| Lightspeed Trustee VIII, LLC | 0 | 2,058,884 | 0 | 2,058,884 | SCHEDULE 13D/A, 2026-06-10 |
The latest filing identifies Personalis, Inc. by CUSIP 71535D106 and gives its principal executive office as 6600 Dumbarton Circle, Fremont, CA 94555 (SCHEDULE 13G/A, 2026-08-14).
Source of funds (Item 3)
Between November 18, 2025 and December 22, 2025, Tempus purchased 320,267 shares of Common Stock in a series of open-market transactions for aggregate consideration of approximately $2.74 million. Tempus funded the purchase of the shares of Common Stock using funds from its working capital.Tempus AI, Inc., SCHEDULE 13D/A, 2026-07-21
Purpose of Transaction (Item 4)
Tempus AI, Inc.
Merger Agreement Following conclusion of confidential preliminary discussions between the Issuer and Tempus, and in response to the Issuer's request for Tempus to submit a proposal, on July 19, 2026, Tempus submitted a non-binding proposal to acquire all of the outstanding Common Stock of the Issuer. On July 20, 2026, Tempus entered into an Agreement and Plan of Merger (the "Merger Agreement") with the Issuer, Aviary Development, Inc., a Delaware corporation and a direct, wholly owned subsidiary of Tempus ("Merger Sub I") and Toucan Development, LLC, a Nevada limited liability company and a direct, wholly owned subsidiary of Tempus ("Merger Sub II" and, together with Merger Sub I, the "Merger Subs"). Pursuant to the Merger Agreement, and upon the terms and subject to the conditions therein, (a) Merger Sub I will be merged with and into the Issuer (the "First Merger"), with the Issuer surviving the First Merger as a direct, wholly owned subsidiary of Tempus (the "First Surviving Corporation"), and (b) as part of the same overall transaction, immediately after the First Merger, the First Surviving Corporation shall merge with and into Merger Sub II (the "Second Merger" and, together with the First Merger, the "Mergers"), with Merger Sub II surviving as a direct, wholly owned subsidiary of Tempus (the "Surviving Company"). The parties intend that the transaction qualify as a reorganization under Section 368(a) of the Code. Capitalized terms used in this Amendment No. 3 but not …The first part of Item 4 of the SCHEDULE 13D/A filed 2026-07-21; the filing has the rest
Timeline
| Filed | Holder | Percent | Filing |
|---|---|---|---|
| 2025-09-12 | Tempus AI, Inc. | 14.5% | SCHEDULE 13D/A |
| 2026-01-08 | T. Rowe Price Investment Management, Inc. | 12.1% | SCHEDULE 13G |
| 2026-01-29 | Orin Hirschman | 3.8% | SCHEDULE 13G/A |
| 2026-02-17 | Ameriprise Financial, Inc. | 7.1% | SCHEDULE 13G |
| 2026-04-08 | T. Rowe Price Investment Management, Inc. | 4.5% | SCHEDULE 13G/A |
| 2026-05-12 | Deep Track Capital, LP | 5.51% | SCHEDULE 13G |
| 2026-06-10 | Lightspeed Venture Partners Select IV, L.P. | 2% | SCHEDULE 13D/A |
| 2026-07-21 | Tempus AI, Inc. | 12.6% | SCHEDULE 13D/A |
| 2026-07-29 | BlackRock, Inc. | 5.9% | SCHEDULE 13G |
| 2026-08-14 | Deep Track Capital, LP | 3.82% | SCHEDULE 13G/A |
| 2026-08-14 | Ameriprise Financial, Inc. | 5.8% | SCHEDULE 13G/A |
Questions about who owns Personalis, Inc.
Who owns Personalis, Inc.?
On this page, 3 holders' latest ownership filings report 5% or more of Personalis, Inc.: Tempus AI, Inc. (12.6%, Schedule 13D/A, filed 2026-07-21), BlackRock, Inc. (5.9%, Schedule 13G, filed 2026-07-29) and Ameriprise Financial, Inc. (5.8%, Schedule 13G/A, filed 2026-08-14).
Who are the largest shareholders of Personalis, Inc.?
By the share each holder's latest filing reports, the largest holders of Personalis, Inc. on this page are Tempus AI, Inc. (12.6%), BlackRock, Inc. (5.9%) and Ameriprise Financial, Inc. (5.8%).
When did Tempus AI, Inc. buy into Personalis, Inc.?
The filings give report dates, not purchase dates. The earliest filing from Tempus AI, Inc. on this page is the Schedule 13D/A, filed 2025-09-12, reporting 14.5%; its latest, Schedule 13D/A filed 2026-07-21, reports 12.6%. That earliest filing is itself an amendment, which updates an earlier report.
Is this an audit or a full list?
Neither. The ownership list on this page covers only Schedule 13D and 13G filings, which holders make once they own 5% or more of a class of shares (an amendment can report a stake that has since fallen below 5%); 11 such filings are shown here. It is not an audit and not a full cap table: holders who never reached 5% are not listed, and a stake can change after its latest filing.
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Where this comes from
Anyone who comes to own more than 5% of a class of a listed company's voting shares has to tell the SEC. A holder who may seek to change or influence the company files Schedule 13D, and has to say in Item 4, "Purpose of Transaction", what it intends to do. A holder with no such intent, such as many index and passive funds, may file the shorter Schedule 13G. Both are amended when the stake changes, including when it falls below 5%.
Every row here is one of those filings, linked to the filing itself. Percentages and share counts are exactly as the holder filed them, for the holder the filing names; an amendment showing a lower figure is shown as filed. Item 4 text is quoted word for word. Where a 13D's Item 4 contains a sentence stating a definite intent to influence the company, that sentence is marked and quoted; the page does not describe the holder or its motives beyond the words it filed. Nothing here is investment advice.